Remove the brisket from the brine, rinsing it off if you used a homemade brine, or soaking the meat for 2 to 4 hours if it was commercially brined
Pat the meat dry, then apply the seasonings as a dry rub. Return the meat to the refrigerator and let the smoker reach 250 degrees F
Place the brisket in the smoker once there is generous smoke being produced by the pellets or chips. Smoke the brisket uncovered for about 30 to 45 minutes per pound, checking the meat after 2 hours or less. Remove the brisket from the smoker when it reaches 170 degrees F internally
Use tongs to move the meat into a roasting pan or aluminum pan that fits in your smoker. Set the meat on a rack, adding a few inches of flavorful liquid to the bottom. Use a tight-fitting lid or aluminum foil to cover the pan
Put the pan in an oven preheated to 300 degrees F or back on the smoker at the same temperature. Braise the meat, checking the temperature every 30 minutes until it rises to 205 degrees internally. Remove it from the oven or smoker and let it rest, still covered, for 10 to 20 minutes before opening and carving