Preheat the oven to 375°F (190°C). Line a baking sheet with parchment paper or aluminum foil
In a deep dish, mix ground beef, breadcrumbs, egg, salt, pepper, garlic powder, and onion powder
Form evenly sized patties, about ¾ inch in thickness, and lightly press on top to create a small dent
Place the patties on the prepared baking sheet and bake for 20-25 minutes, flipping halfway through, until cooked through (internal temperature of 160°F / 70°C)
Remove from the oven and let rest for a few minutes before serving